Institute of Multidisciplinary Research for Advanced Materials, Tohoku University


LAST UPDATE 2021/05/01

  • 研究者氏名
    Researcher Name

    小和田俊行 Toshiyuki KOWADA
    助教 Assistant Professor
  • 所属
    Professional Affiliation

    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

    Division of Organic- and Bio-materials Research
  • 研究キーワード
    Research Keywords

    Photo-responsive Small Molecules
    Functional Fluorescent Molecules
    Fluorescence Imaging
Research Subject
Visualization and manipulation of biological functions using functional small molecules

研究の背景 Background


Visualization of functions of living cells and biomolecules is highly useful for understanding complex biological systems. Moreover, the manipulation of the function of target biomolecules will help us to further understand them. Recently, imaging and controlling various biological functions using optical tools with high spatiotemporal resolution have been attracting more interest.

研究の目標 Outcome


The main objective of our research is to design and synthesize functional small molecules by utilizing the knowledge and techniques of physical and synthetic organic chemistries. Particularly, we aim to develop photo-responsive small molecules for the manipulation of biological functions, as well as fluorescent probes with detectability of biomolecules and environmental changes.

研究図Research Figure

Fig.1. Quantitative imaging of Labile Zn2+ in the Golgi apparatus using a localizable small-molecule fluorescent probe.

Fig.2. Optical manipulation of subcellular protein translocation using a photoactivatable covalent labeling system.

文献 / Publications

ACS Sens. 2022, 7, 748–757.; Angew. Chem. Int. Ed. 2021, 60, 11378–11383.; Cell Chem. Biol. 2020, 27, 1521–1531.; ChemBioChem 2019, 20, 1382–1386.; Nat. Chem. Biol. 2016, 12, 579–585.; J. Am. Chem. Soc. 2011, 133, 17772–17776.