Institute of Multidisciplinary Research for Advanced Materials, Tohoku University


LAST UPDATE 2021/05/01

  • 研究者氏名
    Researcher Name

    高橋聡 Satoshi TAKAHASHI
    教授 Professor
  • 所属
    Professional Affiliation

    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

    有機・生命科学研究部門 生命分子ダイナミクス研究分野
    Division of Organic-and Bio-materials Research, Biological and Molecular Dynamics
  • 研究キーワード
    Research Keywords

    癌抑制タンパク質 p53 の機能
    Protein folding and design
    Tumor suppressor p53
    Single molecule fluorescence spectroscopy
    Single molecule sorting device
Research Subject
Dynamics of proteins based on single molecule fluorescence detection

研究の背景 Background


Proteins are natural polymers that perform various functions that sustain our lives. To be biologically active, proteins, need to form compact three-dimensional structures in the process called protein folding. In addition, the flexible movement of the folded structure is essential for the function of proteins. It is necessary to understand the processes of protein folding and function, and enable the design of artificial proteins.

研究の目標 Outcome


In our laboratory, we develop now single molecule fluorescence spectroscopy and observe the rapid process of protein folding directly. In addition, we observe the functional dynamics, a sliding motion along DNA, of a tumor suppressor p53. Furthermore, based on the knowledge of protein folding and function, we are developing a new strategy to design artificial proteins.

研究図Research Figure

Fig.1. Schematic illustration of the process of protein folding. Denatured proteins can fold to the functional folded structures. Fig.2. Single molecule fluorescence detection system for microsecond resolved time series information. Fig.3. Schematic illustration of the sliding dynamics of p53 along DNA.

文献 / Publications

Sci. Rep., 3, 2151 (2013). J. Am. Chem. Soc., 134, 11525 (2012). Adv. Chem. Phys. 146, 3 (2012).