The Institute of Scientific and Industrial Research, Osaka University


LAST UPDATE 2019/06/17

  • 研究者氏名
    Researcher Name

    鈴木孝禎 Takayoshi SUZUKI
    教授 Professor
  • 所属
    Professional Affiliation

    The Institute of Scientific and Industrial Research, Osaka University

    Department of Complex Molecular Chemistry
  • 研究キーワード
    Research Keywords

    Chemical epigenetics
    Chemical biology
    Medicinal chemistry
Research Subject
Chemical biology and medicinal chemistry study targeting epigenetics

研究の背景 Background


Epigenetics deals with mechanisms of gene expression that do not involve changes in the underlying DNA sequence. It is well known that epigenetics is related to various life phenomena. More importantly, epigenetic aberrations have been found in many abnormal cells and are closely associated with various diseases such as cancer and neurodegenerative disorders. Therefore, controlling epigenetics by small molecules has been of interest both in chemical biology and in epigenetic therapy.

研究の目標 Outcome


Epigenetic mechanisms including DNA methylation and histone modifications are regulated by enzymes. The epigenetic proteins form complexes by protein-protein interactions and protein-lncRNA interactions, which regulates epigenetic gene expression. The objective of this study is to identify small molecules that inhibit the function of the complexes and to apply the small molecules to chemical biology studies and drug discovery.

研究図Research Figure

Fig.1. Design of epigenetic modulators.

Fig.2. Effect of an epigenetic modulator on leukemia cells.

Fig.3. Mechanism analysis of epigenetic modulators using gene expression analysis.

文献 / Publications

J. Med. Chem. 2019, 62, in press (doi: 10.1021/acs.jmedchem.9b00255); Sci. Rep. 2019, 9, 767.; J. Med. Chem. 2018, 61, 10000.; Chem. Sci. 2017, 7, 6400.; Leukemia 2017, 31, 2303.; Cell Rep. 2017, 18, 352.; Angew. Chem. Int. Ed. 2016, 55, 16115.; J. Med. Chem. 2016,59, 1531.; J. Neurosci. 2016, 36, 7253.