Institute for Materials Chemistry and Engineering, Kyushu University


LAST UPDATE 2023/08/08

  • 研究者氏名
    Researcher Name

    趙益成 Ik-Sung CHO
    助教 Assistant Professor
  • 所属
    Professional Affiliation

    Institute for Materials Chemistry and Engineering, Kyushu University

    Division of Soft Materials, Soft Materials Chemistry
  • 研究キーワード
    Research Keywords

    Polymeric biomaterial
    Stimuli responsive
    Self-healing property
    Cell encapsulation
    Cell mechanotransduction
Research Subject

Developing biomaterial strategies to direct cellular functions

研究の背景 Background

Cells utilize tactile mechanisms to physically probe the extracellular matrix. Advances in the design of engineered hydrogels have revealed that various matrix biophysical properties are sufficient to impact cellular functions independently of changes in biochemical cues, including cell-matrix interaction, matrix elasticity, degradation, and stress relaxation. As a result, cells exert traction forces on matrices, and subsequently tune their volume, membrane and intracellular tension. These physical changes affect downstream biological functions, such as stem cell migration, and differentiation, via mechanosensitive transcription factors.

研究の目標 Outcome

I am exploring in a study to investigate how a novel biomaterial affects stem cell behavior, particularly with regards to morphology and differentiation. The study aims to explore how the intermediate water can be regulated by the biomaterial while keeping other factors such as elastic modulus and surface topology. Moreover, not only 2D environment, I am working on how water molecule around single cell regulate cell behavior in 3D environment. This research has potential applications in fields such as tissue engineering, regenerative medicine, and drug discovery.

研究図Research Figure

Fig.1. Thermosensitive hexanoyl glycol chitosan-based ocular delivery system for glaucoma therapy

Fig.2. Defining chemomechanical cues that enhance the production of soluble interstitial collagenases in mouse MSCs.

Fig.3 Asymmetric cell-matrix adhesion leads to polarized membrane tension in single cells.

文献 / Publications

Adv. Sci. 10(3), 2206014 (2022), Nat. Biomed. Eng. 6(1), 54-66 (2021), Chem. Eur. J 26(4), 913-920 (2020), Int. J. Biol. Macromol. 134, 262-268 (2019), Biomater. Res.,22(30), 1-10 (2018), Carbohydr. Polym. 144, 59-67 (2016), Acta Biomater. 39, 124-132 (2016), NPG Asia Mater. 8(9), e309 (2016)