The Institute of Scientific and Industrial Research, Osaka University


LAST UPDATE 2017/02/26

  • 研究者氏名
    Researcher Name

    谷口正輝 Masateru TANIGUCHI
    教授 Professor
  • 所属
    Professional Affiliation

    The Institute of Scientific and Industrial Research, Osaka University

    Department of Bio-Nanotechnology
  • 研究キーワード
    Research Keywords

    Single molecule science
    Single molecule technology
    DNA, RNA, peptides
    Micro/nano-fabrication technologies
Research Subject
1 分子解析技術を用いた生体分子解析
Decoding the biological information of individuals using single molecule science and technologies

研究の背景 Background


Next generation DNA sequencers are very important tool to make a big leap for life science and provide a revolutionary impact to medical science. Not only ultra-high speed and ultra-low cost but high accuracy to sequence DNA and quantitative gene expression level are strongly demanded, in order to apply next generation sequencers to prevention, diagnosis, and therapy for diseases. Single-molecule electrical sequencing technology will be applied to ultrahigh speed and ultralow cost DNA sequencers.

研究の目標 Outcome


Our studies involve the development of single-molecule analytical technologies for DNA, RNA, and protein sequences for genomic and proteomic applications toward disease diagnosis and genomic and personalized medicine. We simultaneously develops single molecule technologies based on single molecule science for detecting and identifying single molecules, manipulating single molecules, controlling dynamics of single molecules

研究図Research Figure

Fig.1. Schematic diagram of identifying single molecules via tunneling currents. Fig.2. Operating principle of single molecule electrical sequencing technology for identifying DNA, RNA, and peptide. Fig.3. Schematic diagram to control the fluid dynamics of single molecules.

文献 / Publications

Nat. Nanotechnol., 5 (2010) 286. Nat. Commun., 1 (2010) 1141. Sci. Rep., 2 (2012) 00501. Nat. Nanotechnol., 9 (2014) 835.