Research Institute for Electronic Science, Hokkaido University


LAST UPDATE 2017/02/25

  • 研究者氏名
    Researcher Name

    西村吾朗 Goro NISHIMURA
    助教 Assistant Professor
  • 所属
    Professional Affiliation

    Research Institute for Electronic Science, Hokkaido University

    Research Center of Mathematics for Social Creativity
  • 研究キーワード
    Research Keywords

    Diffuse optical tomography and diffuse correlation spectroscopy
    Fluorescence fluctuation spectroscopy
    Image reconstruction in a diffusion system
    Time-domain single photon counting method
Research Subject
Quantitative analytical methods for biological systems in vivo by means of the optical technology

研究の背景 Background


The biological system is a cooperative hierarchical system and thus non-invasive analytical methods are required to understand the system. Further, this kind of methods for human is very useful in medical applications. The optical methods among non-invasive methods have a great advantage to measure biological molecules and are significantly investigated. However, the strong scattering and absorption of tissue prevent simple analyses in case of an organ or a body level size sample. The methods to overcome these problems are really needed for quantitative analysis.

研究の目標 Outcome


We investigate methodologies on time-domain near-infrared spectroscopy to quantify the biological molecules and biological monitoring probes in biological tissues. In particular, we are focusing a time-domain method to extract the spatial information, which is lost by the scattering, and aiming to establish the experimental and theoretical methods to quantify the probes. Further, we also wish to combine intensity fluctuation analyses, to quantify the dynamical information in tissue. Finally, we extend our methods to the medical applications

研究図Research Figure

Fig.1.An example of the fluorescence assisted diffuse optical tomography (FADOT). The absorption coefficient of an ICGIntralipid fluorescence target in a cylindrical resin was reconstructed. Fig.2. An example of the diffuse correlation (DCS) measurements. The correlation decay was slowed after death of the rat due to shutoff of the blood flow. Fig.3. An example of the near-infrared fluorescence fluctuation measurements. A newly developed system can simultaneously measure the diffusion property and the fluorescence lifetime.

文献 / Publications

RSC Advance, 4, 41164 (2014). SPIE Proc., 8578, 85782B (2013). Photochem.Photobiol.Sci. 10, 461 (2011). SPIE Proc., 7896, 78962Q (2011). Exp.Mol.Pathol. 82, 175 (2007).