Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology


LAST UPDATE 2020/06/11

  • 研究者氏名
    Researcher Name

    西山伸宏 Nobuhiro NISHIYAMA
    教授 Professor
  • 所属
    Professional Affiliation

    Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology

    Molecular materials design
  • 研究キーワード
    Research Keywords

    Smart functional polymer
    Cancer treatment
Research Subject
Development of smart diagnostic and therapeutic system based on fine-tuned synthetic polymers

研究の背景 Background


In our laboratory, we aim to realize a smart nanomachine that can detect and treat lesions in the body by designing synthetic polymers equipped with various functions such as targetability and environmental responsiveness. Our researches cover development of new materials for in vivo application, delivery of nucleic acid and protein drugs, and realization of new therapeutic methods utilizing bioimaging or physical energy. Also, we are actively collaborating with companies.

研究の目標 Outcome


We are conducting the following 1)-3) projects toward the realization of smart diagnosis and treatment systems based on nanomachines. 1) Synthesis of functional polymers for the construction of smart nanomachines 2) Development of safe and effective nanomachines for various therapeutic modalities including small and medium molecular drugs and biopharmaceuticals such as viral vectors. 3) Development of theranostic nanomachines that realize diagnosis and treatment of intractable diseases.

研究図Research Figure

Fig.1. Cancerous pH-responsive smart shell. The polyzwitterion having ethylenediamine moiety (PGlu(DET-Car)) shows neutral charge at pH7.4 for antifouling but becomes cationic at pH6.5 for enhanced interaction with cancerous tissues [1,2].
Fig.2. Ternary complex micelles from proteins, tannic acid (TA) and boronic acid-modified block copolymers. The micelles displayed prolonged blood circulation and enhanced tumor accumulation of therapeutic proteins [3,4].

文献 / Publications

[1] J. Control. Release 346 392-404 (2022); [2] Angew. Chem. Int. Ed. 57(18) 5057-5061 (2018);
[3] ACS Appl. Mater. Inter. 13(46) 54850-54859 (2021);[4] Biomacromolecules 21(9) 3826–3835 (2020);
[5] Sci. Adv. 6 (4) eaaz1722 (2020)