Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology


LAST UPDATE 2020/06/11

  • 研究者氏名
    Researcher Name

    藤井正明 Masaaki FUJII
    教授 Professor
  • 所属
    Professional Affiliation

    Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology

    Molecular functions
  • 研究キーワード
    Research Keywords

    Advanced Laser Spectroscopy
    Molecular recognition
    Biological moleculer systems
    Gas phase spectroscopy
Research Subject
Study on optical functions and nano-space interactions of molecular building blocks in complex systems

研究の背景 Background


Supramolecules and biomolecules have molecular functions of ultimate efficiencies. For example, the receptor protein recognizes a specific neurotransmitter (e. g. adrenaline) precisely just like “lock and key”. The mechanism of the ultimate functions such as the moleculer recognition can be understood from the view point of the intermolecular interactions. The deep understanding of the mechanism at the moleculer levels is desired because of its importance in chemistry and the related field such as the basic principle for the selforganization to develop the highly functional materials and medicines.

研究の目標 Outcome


Structures and dynamics of functional molecules (building blocks), which concern novel molecular recognitions such as neurotransmitters and partial peptides of receptors, are studied by using originally developed laser desorption spectroscopy in gas phase. Particularly possible conformations of the building blocks are investigated because of their flexibility. From the intermolecular structures of complex at the molecular recognitions, such as the partial peptides of the receptor pocket and neurotransmitters, the mechanism of the molecular recognitions will be revealed.

研究図Research Figure

Fig.1. Laser desorption source for the supersonic jet laser spectroscopy. Fig.2. Conformer-selected UV absorption spectra of DOPA and the DOPA analogue (m-tyrosine). Fig.3. Molecular structure of the ZPLG peptide determined by the laser desorption spectroscopy.

文献 / Publications

S. Ishiuchi et al., Chem. Phys., 419, 145 (2013), Y. Shimozono et al., Phys. Chem. Chem. Phys., 15(14), 5163 (2013), S. Ishiuchi et al., Phys. Chem. Chem. Phys., 13, 7812 (2011), S. Ishiuchi et al., J. Phys. Chem. A 115, 10363 (2011), H. Mitsuda, et al.,J. Phys. Chem. Lett. 1, 1130 (2010),