Institute for Materials Chemistry and Engineering, Kyushu University


LAST UPDATE 2017/02/25

  • 研究者氏名
    Researcher Name

    田中賢 Masaru TANAKA
    教授 Professor
  • 所属
    Professional Affiliation

    Institute for Materials Chemistry and Engineering, Kyushu University

    ソフトマテリアル部門 ソフトマテリアル学際化学分野
    Soft-materials chemistry
  • 研究キーワード
    Research Keywords

    Cell adhesion
    Water structure
Research Subject
Design of biocompatible soft-biomaterials for medical devices

研究の背景 Background


Polymeric soft-biomaterials have significant impact in the aged society. Biocompatible and biodegradable polymers have emerged during the past decades to promise extraordinary breakthroughs in a wide range of diagnostic and therapeutic medical devices. Understanding and controlling the interfacial interactions of the polymeric soft-biomaterials with biological elements, such as water, ions, proteins, bacteria, fungai, and cells are of essential towards their successful implementation in biomedical applications.

研究の目標 Outcome


In order to understand the underlying mechanisms for the biocompatibility of polymers at the molecular level, we have proposed the “Intermediate Water” concept. The intermediate water behaves differently from bulk water and acts as a physical barrier against protein adsorption and platelet adhesion. The objective of the research is to design of the multi-functional biomedical polymers by controlling bio-interfacial water structure through precision polymer synthesis.

研究図Research Figure

Fig.1.Biointerfaces and biointerfacial water layers: Polymeric soft-materials for the medical devices that may come in contact with human blood should have capacity to resist protein adsorption and blood cell adhesion and thus triggering the organism’s defense systems Fig.2.Differential scanning calorimetry heating curve of biocompatible polymer (ex. R1:H, R2 :C2H5, m:2). The intermediate water was only found in hydrated biopolymers (proteins, polysaccharides and nucleic acid; DNA and RNA) and biocompatible synthetic polymers. Fig.3. Cancer cells can attach on Poly(2- methoxyethyl acrylate) (PMEA )and poly(tetrahydrofurfuryl acrylate) (PTHFA) substrates with deformed fibronectin. Platelets cannot attach because fibrinogen deformation is suppressed by intermediate water.

文献 / Publications

ACS Biomater. Sci. Eng, in press, Macromolecules, in press, Biomacromolecules, in press. Macromolecules, 49, 2493-2501, (2016). ACS Appl. Mater. Interfaces, 7, 18096-18103, (2015). Langmuir, 31,7100 (2015).
Langmuir, 31, 3661 (2015). Adv. Healthcare Mater, 3, 775 (2014). Nanomedicine, 10, 313 (2014). Langmuir, 30, 10698 (2014). Polym. J., 47, 114 (2015).