Research Institute for Electronic Science, Hokkaido University


LAST UPDATE 2017/02/25

  • 研究者氏名
    Researcher Name

    玉置信之 Nobuyuki TAMAOKI
    教授 Professor
  • 所属
    Professional Affiliation

    Research Institute for Electronic Science, Hokkaido University

    物質科学研究部門 スマート分子材料研究分野
    Laboratory of Smart molecules, Division of Material and Molecular Sciences
  • 研究キーワード
    Research Keywords

    Molecular Machine
    Science of Molecular Organization
Research Subject
Synthetic approach toward light-driven molecular machines

研究の背景 Background


A molecular machine which can transport molecular loads or generate power is a dream material enabling actively delivering medicines to or autonomously repairing the diseased parts in our body. Nature has developed molecular machines, namely motor proteins, and attains various mechanical works using chemical energy in the living bodies. On the other hand human being has developed synthetic chemistry and the advancement of genetic engineering to enable to create artificially various functional molecules. However, the creation of molecular machines functioning at our will is still an unattained important target for us.

研究の目標 Outcome


The purpose of our study is to develop molecular machines functioning at our will. We think that the usage of light as the source of energy and also as the signal transmitting our command is the best way to accomplish our purpose. We aim the synthetic or semisynthetic creation of molecular machines whose motion is driven or switched by means of light irradiation.

研究図Research Figure

Fig.1. By the photoisomerization of azobenzene unit in AzoTP, the activity as the high energy molecule driving a motor protein kinesin is reversibly changed. Fig.2. By the photoisomerization of azobenzene unit in the macrocyclic molecules, the free rotational motion of rotors is precisely regulated between ON and OFF states.Fig.3. Chiral azobenzenes work as the engine for converting light energy to the rotation in both directions of glass rods in micro meter size on a liquid crystalline film Fig.4 Irradiation of a circularly polarized light induces molecular chirality to achiral molecule

文献 / Publications

ACS Nano, 8, 4157 (2014),. Chem. Commun., 49, 9935 (2013). Chem. Commun., 48, 7625 (2012). Chem. Soc., 6, 873 (2015). Chem.Eur. J., 18, 12337 (2012). Angew. Chem. Int. Ed., 50, 11729 (2012). Chem.Eur. J., 17, 7304 (2011). Chem. Eur. J., 16, 3489 (2010). J. Am. Chem. Soc., 130, 11409 (2008).