Institute for Materials Chemistry and Engineering, Kyushu University


LAST UPDATE 2017/02/25

  • 研究者氏名
    Researcher Name

    狩野有宏 Arihiro KANO
    准教授 Associate Professor
  • 所属
    Professional Affiliation

    Institute for Materials Chemistry and Engineering, Kyushu University

    Advanced Organic Synthesis
  • 研究キーワード
    Research Keywords

    Tumor Biology・Immunology
    Study of Function and Machinery of Bioactive Substances
    New Basis of Sugar Material for Bioactive Reaction
Research Subject
Exploration of Immune Regulatory Factors involved in Tumor Development

研究の背景 Background


The concept of cancer immune surveillance indicates that immune cells recognize and eliminate continuously arising nascent transformed cells. Tumor cells evade immune surveillance and eventually acquire metastatic ability, so now the concept is expanded to “cancer immunoediting”. Particularly, recent advances in tumor immunity suggest that tumor cells much actively suppress T cell activation. Revealing of the detailed machinery of T cell regulation along with tumor development is expected.

研究の目標 Outcome


I found that tumor cells produce immune regulatory factors through analyzing activation of spleen cells isolated from tumor-bearing mice. Now, we are exploring immune regulatory factors and these regulatory mechanisms. So far, we have obtained the results that deny the participation of the several well-known cytokines that suppress immune activation in our observations. We have also found low molecular weight-mediated immune suppressive activities, and aim to determine the responsible compounds for it. We expect that this study would open a window for developing anti-cancer drugs from a new aspect.

研究図Research Figure

Fig.1. Suppression of IFN-γ secretion by splenocytes isolated from 4T1 tumorbearing mice. Fig.2. Quantitative RT-PCR in cultured splenocytes isolated from 4T1 tumor-bearing mice. The fold changes in mRNA expression of IFN-γ, Thy1, and F4/80 with or without 4T1-conditioned medium (4T1CM) compared with the initial levels (3 h culture) are shown.

文献 / Publications

Kano, A. Tumor cell secretion of soluble factor(s) for specific immunosuppression. Sci Rep 5, 9 March (2015).