Institute of Multidisciplinary Research for Advanced Materials, Tohoku University


LAST UPDATE 2021/05/01

  • 研究者氏名
    Researcher Name

    水上進 Shin MIZUKAMI
    教授 Professor
  • 所属
    Professional Affiliation

    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

    有機・生命科学研究部門 細胞機能分子化学研究分野
    Division of Organic- and Bio-materials Research, Cell Functional Molecular Chemistry
  • 研究キーワード
    Research Keywords

    Regulation of cellular functions
    Photofunctional molecules
Research Subject
Imaging and regulation of cellular functions with functional molecule design

研究の背景 Background


In a living body or cell, various biomolecules function by interacting with other molecules. To understand the real biological functions, it is essential to investigate the activities or behaviors of the target biomolecules in living systems, where all of these interactions with other biomolecules are maintained. Recently, a new research field “Chemical biology”, which is a study of biomolecular functions on the basis of chemical approaches has been attracting increasing attention.

研究の目標 Outcome


Using multidisciplinary chemistry such as organic chemistry, macromolecular chemistry, and protein chemistry, we design and synthesize functional molecules, and apply them to image or regulate behaviors or functions of target biomolecules. By combining these functional compounds with the latest imaging technologies, we aim to clarify essential mechanisms of life and various diseases.

研究図Research Figure

Fig.1. Structures of fluorescent probes to investigate cellular functions. Fig.2. Fluorescent images of organella-targeted Mg2+ sensors (top 4 images) and a bone-resorbing osteoclast (bottm image; red: osteoclast, green: acidic compartment, blue: bone). Fig.3. 19F MRI based on perflurocarbonencapsulated silica nanoparticle. TEM image (top right) and in vivo 19F MRI detection of transplanted tumor (botom right).

文献 / Publications

Nat. Chem. Biol., 12, 579 (2016). Angew. Chem. Int. Ed., 524, 1007 (2015). Angew. Chem. Int. Ed. 53, 1008 (2014). Acc. Chem. Res. 47, 247 (2014). J. Am. Chem. Soc. 134, 1623 (2012). J. Am. Chem. Soc. 133, 17772 (2011). J. Am. Chem. Soc. 132, 9524 (2010).