ネットワーク型共同研究拠点を支える 人・環境と物質をつなぐイノベーション創出ダイナミック・アライアンス 研究者データベース

The functional proteins, including enzymes, antibodies, regulatory factors, etc., play essential roles in living organisms. Many of these proteins have been or have the potential to be utilized in the chemical and food industry, medical diagnostics and treatment, and bioremediation. The biomolecular display technologies could serve as rapid and cost-efficient tools for better understanding or improving these functional proteins. The two powerful in vitro display technologies I have been working on have their unique advantages in protein/peptide-related researches. The mRNA display (Fig. 1) can handle a trillion-level library and do a great job in finding the novel targets of interest and describing the fitness

A synergetic effect is expected when different display technologies are working in a consecutive or feedback manner. The primary focus of my current research is on developing a versatile research platform via a combination of mRNA/cDNA display and microbead display and its applications on enzyme engineering, novel enzyme discovery, fitness landscape profiling, and antibody-based fluoroimmunosensor construction.