Institute for Materials Chemistry and Engineering, Kyushu University


LAST UPDATE 2019/06/06

  • 研究者氏名
    Researcher Name

    有馬祐介 Yusuke ARIMA
    准教授 Associate Professor
  • 所属
    Professional Affiliation

    Institute for Materials Chemistry and Engineering, Kyushu University

    Division of Fundamental Organic Chemistry, Nanomaterials and Interfaces
  • 研究キーワード
    Research Keywords

    表面修飾 / 解析
    材料-細胞 / 細胞-細胞間相互作用
    Surface modification / analysis
    Cell-material / cell-cell interaction
Research Subject
Surface design of materials and living cells for biomedical applications

研究の背景 Background


Cell behavior is regulated by its microenvironment, including interactions with soluble factors, extracellular matrices, and neighboring cells in living system. It is crucial to control the cell microenvironment using artificial or natural materials in order to culture cells and to fabricate multicellular tissues in vitro for tissue engineering and regenerative medicine. The understanding of biological responses to materials provides important information on materials design for biomedical applications.

研究の目標 Outcome


We aim at gaining deeper insights into the molecular events at the surfaces of biomaterials and living cells using surface-sensitive analytical techniques and well-defined model system. We also aim at developing surface modification of biomaterials and living cells with artificial or bioactive molecules for cell manipulation including cell culture and formation of multicellular spheroids.

研究図Research Figure

Fig.1. Cell adhesion to model surfaces carrying different functional groups.

Fig.2. Cell surface modification with amphiphilic polymer conjugates for cell manipulation.

Fig.3 Cell-cell attachment to supported lipid bilayer modified with amphiphilic polymer a model cell surface.

文献 / Publications

Acta Biomaterialia, 26, 72-81 (2015).  Biomaterials, 53, 318-329 (2015).  Sci. Technol. Adv. Mater., 17, 677-684 (2016).