Research Institute for Electronic Science, Hokkaido University


LAST UPDATE 2017/02/25

  • 研究者氏名
    Researcher Name

    小松崎民樹 Tamiki KOMATSUZAKI
    教授 Professor
  • 所属
    Professional Affiliation

    Research Institute for Electronic Science, Hokkaido University

    附属社会創造数学研究センター データ数理研究分野
    Research Center of Mathematics for Social Creativity, Molecule & Life Nonlinear Sciences Laboratory
  • 研究キーワード
    Research Keywords

    Single molecule biology
    Molecular data science
    Dynamical systems theory, nonequilibrium statistical mechanics
    Energy landscapes・complex network
Research Subject
Deciphering hierarchy and robustness of living systems from single molecule time series and imaging data

研究の背景 Background


Experimental researches such as single-molecule spectroscopy, molecular imaging are making great breakthroughs to enable us to decipher living systems such as organelles and cells consisting of an enormous number of molecules. On the other hand, it is non-trivial to adopt existing molecular theories which lean on Hamiltonian, dissipative dynamical systems and the like to these more complex systems. Research concerning the development of chemical theories for complex systems is lagging behind significantly, and the development of new data-driven chemical theories and the deep understanding of principle on chance and necessity for changes of states are eagerly awaited.

研究の目標 Outcome


Based on single molecule measurements and imaging techniques to measure the dynamic behavior of molecules in various micro-environmental fields, instead of assuming a molecular model that describes a dynamic system, we construct a new molecular data science in terms of the experimental data. We establish to the principle of chance and necessity for changes of state and our research bridging theory and experiments will involve knowledge of surrounding academic disciplines such as nonlinear physics, mathematical biology, mathematical statistics, and network theory.

研究図Research Figure

Fig.1. Timescale dependent non-equilibrium steady state network showing anomalous diffusion extracted from single molecule energy transfer measurement Fig. 2 Microscopic coordination of microtubules beyond single cells in sepals quantified by a fluorescence intensity profile. Fig.3. Extracting distinct regimes of different chemical micro-environments in terms of single cell Raman spectra

文献 / Publications

(著書)T. Komatsuzaki他"Single Molecule Biophysics: Experiments and Theories" Adv. Chem. Phys., 146, John-Wiley & Sons, Inc (2012).

J. Phys. Chem. B (2019) in press; J. Chem. Phys. 148,123325(2018); Nature Chem. Bio. 13,1009 (2017); Developmental Cell 38,15-32 (2016); Nature Comm. 6,10223 (2015)