Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology


LAST UPDATE 2022/09/07

  • 研究者氏名
    Researcher Name

    奥山浩人 Hiroto Okuyama
    助教 Assistant Professor
  • 所属
    Professional Affiliation

    Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology

    Molecular functions
  • 研究キーワード
    Research Keywords

    Chemical engineering
    Membrane engineering
    Biochemical engineering
Research Subject
Rapid and highly sensitive biomarker detection system for medical diagnosis

研究の背景 Background

近年、疾病や感染症の多様化、高齢化社会の到来によって医療機関の負担が増す中で、在宅・ベッドサイドで行うことが可能な医療検査、すなわちPoint-of-care (POC)検査が注目されています。そこで、多孔質膜の細孔構造をはじめとしたサブミクロンスケールの反応空間を適切に設計することで迅速性と高感度を達成し、現在の医療検査における要求性能を達成しようとしています。

Medical diagnosis that can be performed at home or at the bedside is one of the important techniques for coming aging society. We are trying to achieve the required performance in the current medical tests by appropriately designing the reaction space on the submicron scale including the pore structure of the porous membranes to achieve rapidity and high sensitivity.

研究の目標 Outcome


We aim to construct a highly sensitive and rapid molecular detection method by high-density immobilization of receptors on porous membrane materials and system design through chemical engineering. Now we are also trying to develope sensing materials such as molecular recognition gating membrane which opens and closes pores depending on the presence or absence of specific molecules, and a new molecular recognition membrane that causes coloring in response to target molecules with extremely low concentrations of pM to fM.

研究図Research Figure

Fig.1. Molecular recognition gating membrane which can open/close the pores and change pressure output signals depending on the presence of target molecules.

Fig.2. (above) Membrane-based immunosensor using antigen-antibody system. (below) The recognition performances of membrane-based -immunosensor.

文献 / Publications

H. Okuyama et al., Anal. Chem., 91, 14178–14182, 2019.
H. Okuyama et al., Anal. Chem., 93, 19, 7210–7219, 2021.