Research Institute for Electronic Science, Hokkaido University


LAST UPDATE 2017/02/25

  • 研究者氏名
    Researcher Name

    佐藤勝彦 Katsuhiko SATO
    准教授 Associate Professor
  • 所属
    Professional Affiliation

    Research Institute for Electronic Science, Hokkaido University

    Mathematical and Physical Ethology Lab.
  • 研究キーワード
    Research Keywords

    mathematical modeling for complex phenomena in biology
    continuum mechanics
    reductive perturbation to dynamical systems
Research Subject
Mechanical approaches to biological systems

研究の背景 Background


Since the discovery of DNA double helix, biological systems have been regarded as complex chemical reaction systems and much progress in understandings of it has been achieved. However, recently, many investigators have recognized that mechanical interactions between fundamental components of the biological systems, such as cells and microfilaments of actin, also play an important role in the formation of biological systems. To understand biological systems more completely, we need to take mechanical notions developed in physics into biology

研究の目標 Outcome


We extract essences of interesting phenomena appearing in biological systems by constructing some mathematical models based not only on chemical reactions but also on mechanical principles. To be specific, at the tissue level, we focus on collective migration of epithelial cells, and ask why they can move keeping their attachment with adjacent cells. At the cellular level, we focus on auto-oscillations in muscle, and ask what is the essence of various complex oscillation patterns. At the actomyosin level, we focus on their spontaneous formation of mesoscopic structures due to the flow.

研究図Research Figure

Fig. 1. Unidirectional motion of an cell sheet. A result of numerical simulations of a mathematical model for cell sheets. Fig.2. Spontaneous oscillations in muscle. Spatio-temporal patterns.: (a) in-phase synchronization, (b) traveling wave, (c) disrupted traveling wave, (d) out of phase. Fig.3. Under simple shear flow, actin solutions spontaneously separate into high and low viscous regions.

文献 / Publications

Phys. Rev. Lett. 111 108104 (2013). Phys. Rev. Lett. 109 248303 (2012). Prog. Biophys. Mol. Biol, 105 199-207 (2011). Europhys. Lett. 94 68004 (2011).