Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology


LAST UPDATE 2021/06/03

  • 研究者氏名
    Researcher Name

    三浦一輝 Kazuki MIURA
    助教 Assistant Professor
  • 所属
    Professional Affiliation

    Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology

    Molecular synthesis
  • 研究キーワード
    Research Keywords

    Chemical biology
    Medicinal chemistry
    Bioactive compounds
Research Subject
Development of novel bioactive compounds, and identification of mechanism of action

研究の背景 Background

これまでに様々な疾病に対する医薬品が世の中に上市されてきましたが、未だに治療法のない疾病も数多く存在するのが現実です。このことから、常に新たな医薬品の創出が求められています。しかしながら、新規医薬品開発の成功率は数万分の1と言われ、医薬品まで辿り着くことが可能な生物活性物質を見出すことは容易ではありません。このような背景から、我々はin silico解析などの新たな創薬探索手法を用いて医薬品まで辿り着くことが可能な新規生物活性物質の創出、ならびに新規/既知生物活性物質の作用機序の解明にも取り組んでいます。

Although the medicines have been developed for various diseases, there are still many diseases for which there is no cure. For this reason, there is a constant need to development the novel pharmaceuticals. However, it is difficult to discover a novel bioactive compound that can be leaded to pharmaceuticals. On this background, we have developed a novel bioactive compound for pharmaceuticals using novel drug discovery methods such as computer simulation. Moreover, we try to identify mechanism of action of various bioactive compounds.

研究の目標 Outcome

医薬品へと展開可能な新規生物活性物質の創出を目指します。特にコンピュータを用いたin silico解析や独自に構築したプローブおよび細胞アッセイ系など、ドライおよびウェットの両研究視点から創薬研究にアプローチしています。また、化学と生物学が融合した分野であるケミカルバイオロジーなど、様々な分野のアプローチ方法を用いて生物活性物質の細胞内作用機序の解明等の創薬研究にも挑戦しています。

Our research purpose is the development of novel applicable bioactive compounds for the pharmaceuticals. In particular, we approach the drug discovery study using dry and wet studies, such as in silico analysis and originally constructed probe and cell-based assay systems. Moreover, using various chemical biology approaches, we identify intracellular mechanism of action of bioactive compounds such as anti-cancer activity compounds.

研究図Research Figure

Fig.1. Identified bioactive compounds and an example of analyzing the mechanism of action of the compound.

Fig.2. Analysis of active site structure of the enzyme and development of a novel inhibitor using in silico simulation.

文献 / Publications

Biochim. Biophys. Acta Gen. Subj. 1865, 129833 (2021), Bioorg. Med. Chem. 34, 116041 (2021),Trends Glycosci. Glycotechnol. 32, E201-E204 (2020),Chem. Pharm. Bull. 68, 753-761 (2020), Chem. Pharm. Bull. 68, 526-533 (2020), Bioorg. Med. Chem. 28, 115253 (2020), ACS Med. Chem. Lett. 10, 1309-1313(2019), Bioorg. Med. Chem. 24, 1169-1375 (2016).