Research Institute for Electronic Science, Hokkaido University


LAST UPDATE 2020/11/09

  • 研究者氏名
    Researcher Name

    三上秀治 Hideharu MIKAMI
    教授 Professor
  • 所属
    Professional Affiliation

    Research Institute for Electronic Science, Hokkaido University

    生命科学研究部門 光情報生命科学研究分野
    Laboratory of Information Biophotonics, Division of Biology and Life Sciences
  • 研究キーワード
    Research Keywords

    High-speed bio-imaging
    Large-scale 3D fluorescence imaging
    Image data analysis of biological tissues using deep learning
    Optogenetic control of living organisms by lightwave engineering
Research Subject
High-speed optical access to biological tissues by the integration of optics and informatics

研究の背景 Background


Light has long been a useful tool for observing and manipulating biological samples, and especially in the 21st century, it has become increasingly important with the development of technologies for manipulating fluorescent and photoresponsive proteins. In recent years, the amount of data handled has increased dramatically along with the increase in dimensionality of the data have brought the amount of information acquired from biological samples to a standstill. In order to overcome this situation, there is a strong need for "smart" optical technology that can more efficiently access biological samples and acquire the desired information.

研究の目標 Outcome


We approach the above issues by integrating optical technologies and information technologies. Specifically, we aims to shed light to unexplored life phenomena by exploring the limits of information-theoretic imaging speed and sensitivity, extracting information from imperfect optical images specialized for desired information, and developing methods to control optical imaging and optical manipulation in an integrated manner.

研究図Research Figure

Fig.1. High-speed 3D fluorescence microscope that has volume rates over 100 volumes/sec.

Fig.2. Volumetric image of neurons of Caenorhabditis elegans that express Yellow Cameleon 2.60.

文献 / Publications

Lab on a Chip 20, 3074-3090 (2020). Nature Communications 11, 3452 (2020). Lab on a Chip 20, 2263-2273 (2020). Nature Communications 11, 1162 (2020). Nature Protocols 14, 2370–2415 (2019). Cell 175(1), 266-276.e13 (2018). Chem 4(10), 2278-2300 (2018). Biomed. Opt. Express 9(7), 3424-3433 (2018). Optica 5(2) 117-126 (2018).