IMCE

Institute for Materials Chemistry and Engineering, Kyushu University

九州大学
先導物質化学研究所

LAST UPDATE 2017/02/25

  • 研究者氏名
    Researcher Name

    田中賢　Masaru TANAKA
    教授　Professor

  • 所属
    Professional Affiliation

    九州大学先導物質化学研究所
    Institute for Materials Chemistry and Engineering, Kyushu University

    ソフトマテリアル部門 ソフトマテリアル学際化学分野
    Soft-materials chemistry

  • 研究キーワード
    Research Keywords

    生体適合性
    細胞接着
    バイオ界面
    水和構造
    Biocompatibility
    Cell adhesion
    Bio-interfaces
    Water structure
研究テーマ
Research Subject
生体適合性に優れた診断・治療用ソフトバイオマテリアルの設計
Design of biocompatible soft-biomaterials for medical devices

研究の背景 Background

高分子ソフトバイオマテリアルは、高齢化社会において重要な役割を担っている。生体親和性と生分解性を有する高分子は、診断・治療用の医療製品開発のブレークスルーのためには必須である。高分子ソフトバイオマテリアルと水・イオン・タンパク質・微生物・細胞などの生体成分の相互作用の理解と制御が、バイオメディカル製品開発の最重要項目である。

Polymeric soft-biomaterials have significant impact in the aged society. Biocompatible and biodegradable polymers have emerged during the past decades to promise extraordinary breakthroughs in a wide range of diagnostic and therapeutic medical devices. Understanding and controlling the interfacial interactions of the polymeric soft-biomaterials with biological elements, such as water, ions, proteins, bacteria, fungai, and cells are of essential towards their successful implementation in biomedical applications.

研究の目標 Outcome

合成高分子バイオマテリアルの生体適合性発現機構の分子レベルで理解するために、材料と生体成分が接触する環境に存在する水分子に着目し、中間水コンセプトを提案している。本研究では、主鎖、側鎖を系統的に変化させた高分子を精密合成することでバイオ界面水を制御し、次世代の診断・治療用医療機器のための分子設計指針の構築を目指しています。

In order to understand the underlying mechanisms for the biocompatibility of polymers at the molecular level, we have proposed the “Intermediate Water” concept. The intermediate water behaves differently from bulk water and acts as a physical barrier against protein adsorption and platelet adhesion. The objective of the research is to design of the multi-functional biomedical polymers by controlling bio-interfacial water structure through precision polymer synthesis.

研究図Research Figure

Fig.1.Biointerfaces and biointerfacial water layers: Polymeric soft-materials for the medical devices that may come in contact with human blood should have capacity to resist protein adsorption and blood cell adhesion and thus triggering the organism’s defense systems Fig.2.Differential scanning calorimetry heating curve of biocompatible polymer (ex. R1:H, R2 :C2H5, m:2). The intermediate water was only found in hydrated biopolymers (proteins, polysaccharides and nucleic acid; DNA and RNA) and biocompatible synthetic polymers. Fig.3. Cancer cells can attach on Poly(2- methoxyethyl acrylate) (PMEA )and poly(tetrahydrofurfuryl acrylate) (PTHFA) substrates with deformed fibronectin. Platelets cannot attach because fibrinogen deformation is suppressed by intermediate water.

文献 / Publications

The Intermediate Water Concept for Pioneering Polymeric Biomaterials: Bull. Chem. Soc. Jpn., 96, 1052 (2023). Adv. Drug Deliv. Rev., 198, 114895 (2023). Biomacromolecules, 23, 2999 (2022). ACS Biomater. Sci. Eng., 8, 4547 (2022). J. Phys. Chem. B, 126, 4143 (2022). Biomacromolecules, 23, 2999 (2022). Macromolecules, 55, 15 (2022). ACS Biomater. Sci. Eng., 8, 672 (2022). Langmuir, 38, 1090 (2022). J. Phys. Chem. B, 126, 1758 (2022). Adv. Mater. Interfaces, 202200707 (2022). Adv. Drug Deliv. Rev., 186, 114310 (2022). Science Advances, 7, eabi6290 (2021). Biomacromolecules, 22, 1569 (2021). Macromolecules, 54, 8067 (2021). Macromolecules, 54, 2862 (2021). ACS Biomater. Sci. Eng., 7, 2383 (2021). J. Phys. Chem. B, 125, 7251 (2021). Langmuir, 37, 8534 (2021). Macromolecules, 54, 8067 (2021). ACS Biomater. Sci. Eng., 6, 6690 (2020). Macromolecules, 53, 8570 (2020). ACS Appl. Polym. Mater., 2, 4749 (2020). ACS Biomater. Sci. Eng., 6, 3915 (2020). ACS Biomater. Sci. Eng., 6, 2855 (2020). ACS Appl. Bio Mater., 3, 1858 (2020). Biomacromolecules, 20, 2265 (2019). Langmuir, 35, 2808 (2019). ACS Appl. Bio Mater., 3, 981(2019). ACS Appl. Bio Mater., 2, 4154 (2019). Adv. Healthcare Mater., 8, 1900130 (2019). Science Advances, 4, eaau2426 (2018). etc.

研究者HP