The Institute of Scientific and Industrial Research, Osaka University


LAST UPDATE 2017/02/26

  • 研究者氏名
    Researcher Name

    笹井宏明 Hiroaki SASAI
    教授 Professor
  • 所属
    Professional Affiliation

    The Institute of Scientific and Industrial Research, Osaka University

    Division of Biological and Molecular Science, Department of Synthetic Organic Chemistry
  • 研究キーワード
    Research Keywords

    Asymmetric catalysis
    Optically active compounds
    Organic synthesis
    Molecular transformation
Research Subject
Development of highly practical molecular transformation based on enantioselective catalysis

研究の背景 Background


Optically active compounds are applied to a wide variety of manufactured products such as pharmaceutical agents, agrochemicals, and fragrances. Since the demand of optically active compounds has recently been increasing, efficient synthetic strategy for them is needed to be developed. Catalytic asymmetric synthesis, which is recognized as the most useful and green synthetic method of optically active compounds, should be further innovated.

研究の目標 Outcome


Towards the development of versatile synthetic transformation processes utilizing enantioselective catalysis, novel chiral ligands and organocatalysts are designed, prepared, and applied to the energy-saving and environmentally-benign reactions. The mechanisms of these catalytic reactions are also studied by means of physical organic techniques.

研究図Research Figure

Fig.1. X-ray structure of a unique chiral ligand bearing isoxazoline donors based on a spiro skeleton, i-Pr-SPRIX. Fig.2. X-ray structure of oxa[9]helicene, which was obtained via enantioselective coupling of benzo[c]-2-phenanthrol catalyzed by V catalyst. Fig.3. Design concept of bifunctional chiral organocatalysts and asymmetric formal [n+2] cycloaddition reactions promoted by a chiral organocatalyst.

文献 / Publications

Chem. Commun., 49, 8392 (2013). Chem. Commun., 49, 11224 (2013). Asian. J. Org. Chem., 3, 412 (2014). Angew. Chem. Int. Ed., 53, 4675 (2014). Org. Lett., 16, 4162 (2014).
Org. Biomol. Chem., 13, 4837 (2015). Chem. Eur. J., 21, 8992 (2015). Angew. Chem. Int. Ed., 54, in press (2015) (doi: 10.1002/anie.201504552).